Greg Isenberg

Vinny demos Buzz, Block's open-source agent-native chat app where agents are first-class teammates, the harness under each agent swaps…

Cody Schneider defines a real marketing agent (owns unified data, runs on a cadence, learns from its own results) and uses an AI-first…

Ryan Carson returns (Treehouse, ~110 employees, ~1M learners) to walk through his solo-agent stack at Untangle, an AI divorce agent for…

Vas from Varick Agents (a forward-deployed engineering firm) breaks down the AI FDE role, tracing it to Palantir's on-site engineers who…

Greg interviews Corey Ganim on his $999, 45-minute AI Tools Assessment for small businesses ($500K-$5M revenue). Fulfillment is four…

Elie Steinbock (New Form) unpacks loop engineering, the lean startup / Toyota build-measure-learn loop turned into AI agents that run on a…

Nick Vasilescu (Orgo) argues Grok 4.5 is the model that finally lets you treat AI as a co-founder, not just automation. He demos spinning…

Dan Shipper shows how he runs work and personal life inside OpenAI's Codex Desktop with GPT 5.6: card-based email, daily company/Slack…

Greg's agent-SaaS playbook: pick a workflow that already has a paycheck attached, shadow the human for 10–20 jobs, ship a minimum useful…

Solo episode laying out six skills Greg argues stay valuable as AI improves: running AI agents and local models, marketers who build…

With Amir, a tactical look at running GLM 5.2 from ZAI daily: 1M-token context, 81 on Terminal Bench 2.1, the 'fusion' approach sequencing…

Greg sits with 19-year-old George Lampropoulos on his framework for AI-built mobile apps hitting $10K/mo (~333/day). Numbers: WrestleAI hit…

Solo episode on the rationale for owning a private local-AI layer after a US-government letter took Fable 5 offline overnight. Walks…

Solo episode on tactical Fable 5 use cases: an Anthropic employee uses Fable to cut a launch video from 17 takes across four scenes…

Ras Mic defines an agentic loop (single human fire, agent generates/reviews/feeds back) and argues that human-in-the-loop remains the…

Theo joins to define an AI-native org as people managing agents, agents reading and writing to the company, and the company growing smarter…

Alex Finn walks through Hermes Desktop, an Apple-style agent interface with sessions, model-mapped profiles (Opus for strategy, ChatGPT for…

Greg solo walkthrough of Codex Sites, the OpenAI tool for self-updating apps that an agent keeps operating. Compared with Replit and…

Solo episode mapping the shift from human-first to agent-first internet: AI agents discover, evaluate, pay and recommend, and need new…

Jonathan Courtney and Greg trade nine big 2026 startup ideas: Twitch-style unscripted tech shows, agent-first action apps, paid niche…

Nick from Orgo breaks down the $1M+ solo AI agent business: offer design, the verticals worth chasing (and two to avoid), the full software…

Walk-through of seven tiny cash-flowing startup ideas using Genspark Claw (Sonnet 4.6 in the cloud, ~$25/mo): dead-domain flipper, local…

Meng To returns to walk through Google's new design md format (a portable blueprint for typography, color, spacing, effects) and how he…

Andrew Wilkinson (Tiny, multi-company family office) on restructuring work around AI agents: Deep Personality (vibe-coded ~$20K/mo app),…